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- Title
侧脑室微量注射大麻素受体拮抗剂对orexin-A诱导大鼠能量代谢改变的影响及潜在机制研究.
- Authors
刘金政; 王茜; 冷慧; 高胜利; 郭菲菲; 孙向荣; 徐珞
- Abstract
Objective: To investigate the effects of the cannabinoid type 1 receptor (CB1) inhibitor rimonabant on the energy metabolism and related behavioral changes induced by microinjection of orexin-A into the lateral hypothalamic area (LHA). Methods: Microinjection of rimonabant into the lateral ventricle (icv) and microinjection of orexin-A into LHA were used to measure changes in energy metabolism, autonomous movement, dopamine release in the amygdala (CeA), and changes in food intake in mice. Results: The results showed that microinjection of rimonabant into lateral ventricle could attenuate the changes of energy metabolism induced by microinjection of orexin-A into LHA, decrease the spontaneous movement of mice, and weaken the ability of dopamine release in CeA of mice. Rimonabant injection of (icv) did not change the increase of food intake induced by microinjection of orexin-A into LHA. In addition, it was found that bilateral injection of rimonabant into LHA could block the promoting effect of orexin-A injection into LHA on exercise activity, but did not affect the food intake of mice. Conclusions: Cannabinoid receptors are involved in orexin-A-induced regulation of dopaminergic system activation in the midbrain system of mice, and have an effect on energy metabolism and autonomic movement, but have no significant effect on food intake regulation.
- Subjects
CANNABINOID receptors; INGESTION; ENERGY metabolism; BEHAVIOR; MICROINJECTIONS
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 2, p248
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.02.009