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- Title
下丘脑室旁核orexin-A对大鼠摄食和胃动力影响及调控机制.
- Authors
王金鹏; 王咪; 郭菲菲; 徐珞
- Abstract
Objective: To study the effect of orexin-A on the feeding and gastric motility of rats in paraventricular nucleus and its regulatory mechanism. Methods: The expression of PVN orexin receptor was observed by immunohistochemistry. The changes of food intake, gastric motility, gastric acid secretion and gastric emptying were observed after PVN injection of orexin-A. Results: Immunohistochemistry showed orexin receptor-positive immunoreactive cells in the PVN of rats. After PVN injection of orexin-A, the feeding of rats increased in the first three hours, and there was no significant change in 6h and 24 h. After microinjection of orexin-A into PVN, the gastric motility amplitude and frequency, gastric emptying and gastric acid secretion of rats were increased. [D-Lys-3]-GHRP-6 partially blocked the promotion of food intake, gastric motility, gastric emptying and gastric acid secretion by orexin-A. SB334867 completely blocked the promotion of orexin-A on gastric motility, gastric emptying and gastric acid secretion. Conclusion: Orexin-A in the hypothalamic paraventricular nucleus could regulate the feeding and gastric function through GHSR receptor signaling pathway.
- Subjects
OREXINS; LABORATORY rats; PARAVENTRICULAR nucleus; IMMUNOHISTOCHEMISTRY; GASTROINTESTINAL motility
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 14, p2647
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.14.009