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- Title
人附睾蛋白4 与糖类抗原125 在子宫内膜癌诊治中的临床价值.
- Authors
崔彭华; 张玉娟; 邵雪斋; 王会民; 申兴彬
- Abstract
Objective: To investigate the clinical value of human epididynial protein 4 (HE4) and carbohydrate antigen 125 (CA-125) in the diagnosis and treatment of endometrial carcinoma (EC). Methods: 60 cases of patients with EC (EC group) and 60 cases of patients with dysfunctional uterine bleeding (DUB) (DUB group) were selected for the present study. 60 cases of healthy women were enrolled as the normal control (NC group). Enzyme linked immunosorbent assay (ELJSA) and electrochemiluniinescence (ECLA) were performed for detecting the lewis of serum HE4 and CA-125. respectively. The differences of serum HE4 and CA-125 levels among the three groups were compared, and ROC curve was drawn to evaluate the diagnostic efficacy of single and combined detection of two index on EC. Results: The levels of serum HE4 [(141.16± 46.43) pmotL] and CA-125 [(33.14± 7.52) U/mL] in the group EC were significantly higher than those in the group DUB and group NC (P< 0.05). Compared with the NC group, the level of serum CA-125 [(19.05± 7.20) U/mL] in the group DUB was significantly higher (P<0.05). but there was no significant difference of HE4 level between them (P>0.05). The levels of serum HE4 [(172.04± 18.66) pniolL] and CA-125 [(45.05± 4.11) U/mL] in EC patients with stage III were significantly higher than those in EC patients with stage II andstage I (P<0.05). The positive rates of HE4 in EC stage I (67.9%) was significantly higher than that of CA-125 (P<0.05). The critical values of HE4 and CA-125 for EC diagnosis were 65.42 pniolL and 25.53 U/mL. respectively. The sensitivity of HE4 and CA-125 for EC diagnosis were 97.5% and 78.3%. respectively. The specificity were 95.0% and 98.3%. respectively. The area under the curve (AUC) were 0.993 and 0.954. respectively. The sensitivity, specificity and AUC of HE4 and CA-125 combined detection for EC diagnosing were 99.2%. 95.0% and 0.995. respectively. Compared with the preoperative. the levels of serum HE4 [(45.13± 8.06) pniolL] and CA-125 [(11.22± 5.50) UniL] in the postoperative EC patients were significantly lower (P<0.05). Conclusions: A monitoring of serum HE4 level had important reference value for the diagnosis, preoperation and efficacy evaluation of EC. and its combined detection with CA-125 can improve the accuracy of EC diagnosis.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 12, p2334
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.12.028