We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
阿替普酶与巴曲酶治疗急性脑梗死的疗效比较及对患者血清NSE、IL-6、TNF-α、hs-CRP水平的影响
- Authors
李海军; 高晓嵘; 吴瑞; 尚雪峰; 张鹏轩; 王玉娟
- Abstract
Objective: To observe and compare the clinical effect of alteplase (rt-PA) and batroxobin in the treatment of acute cerebral infarction (ACI) and its effects on the serum neuron specific enolase (NSE), interleukin-6 (IL-6), tumor necrosis factor-琢 (TNF-琢) and high sensitive C reactive protein (hs-CRP) levels. Methods: 106 cases of ACI patients admitted in our hospital from June 2014 to December 2016 were selected and divided into two groups according to the randomnumber table method. The control group was treated with batroxobin, while the observation group was treated with rt-PA. The clinical efficacy; changes of serum NSE, IL-6, TNF-α and hs-CRP levels before and after treatment and the incidence of adverse reactions during treatment were compared between two groups. After 14days' treatment, the total effective rate of observation group was 81.1%, which was significantly higher than that of the control group (62.3%)(P<0.05). The serum NSE, IL-6, TNF-α and hs-CRP levels in both groups at 14 day after treatment were significantly lower than those before treatment (P<0.01), and the above indexes at 14 day after treatment in the observation group were significantly lower than those of control group in the same period (P<0.01). The incidence rate of adverse reactions was 7.5%in the observation group and compared with the control group (1.9%), there was no significant difference (P>0.05). Compared with batroxobin, alteplase intravenous thrombolytic therapy could more effectively control the inflammation state and improve the nerve function defect for the patients with acute cerebral infarction.
- Subjects
ALTEPLASE; SNAKE venom; CEREBRAL infarction; ENOLASE; PATIENTS; THERAPEUTICS; THERAPEUTIC use of venom
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 7, p1330
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.07.028