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- Title
甲泼尼龙琥珀酸钠对外伤性脑水肿患者血清NO、ET、LPO和SOD水平 的影响.
- Authors
康健; 李胜龙; 杨金坤; 樊拥军; 韦有佩
- Abstract
Objective: To observe the efficacy of methylprednisolone sodium succinate in the treatment traumatic brain edema and effect on the serum nitric oxide (NO), endothelin (ET) and lipid peroxide (LPO) and superoxide dismutase (SOD) levels. Methods: 104 cases of patients with traumatic brain edema from November 2014 to November 2016 were divided into the control group and the research group according to the treatment mode, both groups were treated for seven days. The control group was treated with conventional treatment, and the research group was treated with methylprednisolone sodium succinate based on control group. The clinical curative effect, changes of serum NO, ET and LPO, SOD, cerebral edema volume, National Institutes of Health Stroke Scale (NIHSS) and Glasgow coma scale (GCS) before and after the treatment, and incidence of complications were observed and compared between two group. Results: The total effective rate of research group was higher than that of the control group (P〈0.05). Before treatment, no significant difference was found in the serum NO, ET, LPO, SOD levels, cerebral edema volume, NIHSS, GCS NO between two groups (P〉0.05). After treatment, the serum NO, SOD, GCS levels of both group were markedly higher than those of the control group, which were significantly higher in the research group than those of the control group, the serum ET and LPO, NIHSS, cerebral edema volume of both groups were significantly lower than those before treatment, which were significantly lower in the the research group than those of the control group (P〈0.05). There was no statistically significant difference in the incidence of complications between the two groups (P〉0.05). Conclusion: Prednisolone sodium succinate could effectively enhance the clinical efficacy of traumatic cerebral edema, which might be related to significant regulation of the serum levels of NO, ET, LPO, SOD.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 5, p911
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.05.024