We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.
- Authors
Srinivasan, Shriya S.; Alshareef, Amro; Hwang, Alexandria V.; Kang, Ziliang; Kuosmanen, Johannes; Ishida, Keiko; Jenkins, Joshua; Liu, Sabrina; Madani, Wiam Abdalla Mohammed; Lennerz, Jochen; Hayward, Alison; Morimoto, Josh; Fitzgerald, Nina; Langer, Robert; Traverso, Giovanni
- Abstract
Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. Luminal mucus represents the initial steric and dynamic barrier to absorption. To overcome this barrier, we report the development of the RoboCap, an orally ingestible, robotic drug delivery capsule that locally clears the mucus layer, enhances luminal mixing, and topically deposits the drug payload in the small intestine to enhance drug absorption. RoboCap's mucus-clearing and churning movements are facilitated by an internal motor and by surface features that interact with small intestinal plicae circulares, villi, and mucus. Vancomycin (1.4 kilodaltons of glycopeptide) and insulin (5.8 kilodaltons of peptide) delivery mediated by RoboCap resulted in enhanced bioavailability 20- to 40-fold greater in ex vivo and in vivo swine models when compared with standard oral delivery (P < 0.05). Further, insulin delivery via the RoboCap resulted in therapeutic hypoglycemia, supporting its potential to facilitate oral delivery of drugs that are normally precluded by absorption limitations.
- Subjects
GASTROINTESTINAL agents; ORAL medication; DRUG absorption; PEPTIDES; DRUG administration; SMALL intestine; GASTROINTESTINAL system
- Publication
Science Robotics, 2022, Vol 7, Issue 70, p1
- ISSN
2470-9476
- Publication type
Article
- DOI
10.1126/scirobotics.abp9066