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- Title
Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study.
- Authors
Häge, Alexander; Man, Kenneth K. C.; Inglis, Sarah K.; Buitelaar, Jan; Carucci, Sara; Danckaerts, Marina; Dittmann, Ralf W.; Falissard, Bruno; Garas, Peter; Hollis, Chris; Konrad, Kerstin; Kovshoff, Hanna; Liddle, Elizabeth; McCarthy, Suzanne; Neubert, Antje; Nagy, Peter; Rosenthal, Eric; Sonuga-Barke, Edmund J. S.; Zuddas, Alessandro; Wong, Ian C. K.
- Abstract
Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited. Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study. Participants were recruited into three groups: ADHD patients intending to start MPH-treatment (MPH-group), those not intending to use ADHD-medication (no-MPH-group), and a non-ADHD control-group. Sleep problems were assessed with the Children's-Sleep-Habits-Questionnaire (CSHQ). Results: 1,410 participants were enrolled. Baseline mean CSHQ-total-sleep-scores could be considered clinically significant for the MPH-group and the no-MPH-group, but not for controls. The only group to show a significant increase in any aspect of sleep from baseline to 24-months was the control-group. Comparing the MPH- to the no-MPH-group no differences in total-sleep-score changes were found. Conclusion: Our findings support that sleep-problems are common in ADHD, but don't suggest significant negative long-term effects of MPH on sleep.
- Subjects
SLEEP; METHYLPHENIDATE; ATTENTION-deficit hyperactivity disorder; TEENAGERS
- Publication
Journal of Attention Disorders, 2024, Vol 28, Issue 5, p699
- ISSN
1087-0547
- Publication type
Article
- DOI
10.1177/10870547241232337