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- Title
Microbial epidemiology and risk factors of infections in recipients after DCD liver transplantation.
- Authors
Zhang, M.-L.; Xu, J.; Zhang, W.; Liu, X.-Y.; Zhang, M.; Wang, W.-L.; Zheng, S.-S.
- Abstract
<bold>Aim: </bold>Infection is a major cause of increased mortality after a liver transplant (LT). This study sought to identify the incidence, prevalence and risk factors of microbial infection for recipients who underwent LT using grafts from donors after cardiac death (DCD).<bold>Methods: </bold>We retrospectively analysed the frequency and characteristics of post-transplantation infections in 236 recipients who underwent DCD LT between 1 January 2010 and 31 December 2014 in our centre and evaluated the risk factors of post-transplantation infection.<bold>Results: </bold>Overall, 162 recipients acquired at least one type of infection during hospitalisation after LT, and the morbidity rate was 68.6%. Moreover, 19 of the 236 recipients died, with an overall mortality rate of 8.1%. In total, 752 pathogens were isolated. Gram-positive bacteria, Gram-negative bacteria and fungi accounted for 26.1% (196), 58.2% (438) and 15.7% (118) of the pathogens, respectively. Kaplan-Meier curves of 1-year survival showed that recipients with infection had a significantly lower cumulative survival rate compared with those without infection (83.2% vs. 90.6%, p < 0.05). Multivariate analysis revealed that age > 60 years (p = 0.010) and severe hepatitis (p = 0.036) were independent risk factors for infection during hospitalisation after LT.<bold>Conclusion: </bold>Infection is a common complication after a DCD-LT that could impair 1-year survival. We suggest physicians pay more attention to the infection of recipients post-LT, especially those recipients greater than 60 years of age and those who suffered from severe hepatitis.
- Subjects
CHINA; GRAM-negative bacterial diseases; LIVER transplantation; MYCOSES; SURGICAL complications; SURVIVAL analysis (Biometry); TRANSPLANTATION of organs, tissues, etc.; GRAM-positive bacterial infections; RETROSPECTIVE studies
- Publication
International Journal of Clinical Practice, 2016, Vol 70, p17
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.12812