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- Title
Synthesis and micellar characterization of luteinizing hormone-releasing hormone poly(ethylene glycol)- block-poly( l-histidine) copolymers.
- Authors
Li, Fei; Fan, Li; Li, Wei; Duan, Xiao; Qiao, Youbei; Wu, Hong
- Abstract
A facile and well-controlled pathway was introduced to obtain optimal pH-sensitive luteinizing hormone-releasing hormone-functionalized poly(ethylene glycol)- block-poly( l-histidine) (LHRH-PEG-PHIS) micelles in this paper. The influence of block-selective solvent, the weight ratio of the selective solvent to common solvent and initial polymer concentration on the self-assembly of LHRH-PEG-PHIS micelles were studied. These factors exerted remarkable influence on the morphology of the resulting micelles. The micelles showed a spherical geometry and an uniform appearance under the following optimal experimental conditions: LHRH-PEG/PHIS ratio of 1.0 by molar, DMF as the selective solvent and 3.0 mg/mL as initial concentration, 100 W of ultrasonic power. These micelles had a small diameter (about 90 nm), low CMC (10 μg/mL), and pH-sensitive switch in surface charge and micelles' size. As the pH of the micellar solution decreased from pH 7.4 to 5.5, the zeta potential of the LHRH-PEG-PHIS micelles increased from −0.02 mV to 20.7 mV and the diameter of the nanoparticles decreased from 137 nm to 76 nm. After 30 h of incubation at pH 5.0, 6.0, and 7.4 the released free Doxorubicin (DOX) was about 83.18%, 81.26%, and 30.35%, respectively. The LHRH-PEG-PHIS micelles could combine the characteristics of active targeting with pH-triggered drug release promising as intracellular drug delivery carriers. POLYM. ENG. SCI., 55:277-286, 2015. © 2014 Society of Plastics Engineers
- Subjects
MICELLAR catalysis; LUTEINIZING hormone releasing hormone; HISTIDINE; COPOLYMERS; SPHERICAL trigonometry; SURFACE charges; DOXORUBICIN
- Publication
Polymer Engineering & Science, 2015, Vol 55, Issue 2, p277
- ISSN
0032-3888
- Publication type
Article
- DOI
10.1002/pen.23892