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- Title
Impact of pulmonary hypertension on exercise performance in patients with interstitial lung disease undergoing evaluation for lung transplantation.
- Authors
Armstrong, Hilary F.; Schulze, P. Christian; Bacchetta, Matthew; Thirapatarapong, Wilawan; Bartels, Matthew N.
- Abstract
Background and objective Pulmonary hypertension ( PH) is a known complication in patients with interstitial lung disease ( ILD). Cardiopulmonary exercise testing ( CPET) is an essential tool for the assessment of patients with cardiac and pulmonary diseases due to its prognostic and therapeutic implications. Few studies have evaluated the relationship between CPET response and mean pulmonary artery pressures ( mPAP) in ILD. The purpose of the present study was to determine and compare the potential correlations between CPET, 6-min walk test (6 MWT), pulmonary function testing ( PFT) and PH in patients with ILD being evaluated for lung transplantation. Methods The present study reviewed patients with ILD who received lung transplantations and had CPETs within 2 years before transplantation, right heart catheterizations, PFTs and 6 MWTs within 4 months of CPET. Results A total of 72 patients with ILD were analysed; 36% had PH. There were significant correlations between mPAP and CPET parameters in patients with PH; but mPAP had no impact on percent of predicted diffusion capacity of the lung for carbon monoxide or 6-min walk distance (6 MWD). CPET parameters were able to detect differences between levels of severity of PH through the use of the ratio of minute ventilation to rate of carbon dioxide production (
- Subjects
CARDIOPULMONARY fitness; INTERSTITIAL lung diseases; TRANSPLANTATION of organs, tissues, etc.; RESPIRATORY disease risk factors; LUNG disease treatment; PULMONARY function tests; DIAGNOSIS
- Publication
Respirology, 2014, Vol 19, Issue 5, p675
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12306