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- Title
Triggering receptor expressed on myeloid cells-1 and 2 in bronchoalveolar lavage fluid in pulmonary sarcoidosis.
- Authors
Suchankova, Magda; Bucova, Maria; Tibenska, Elena; Tedlova, Eva; Demian, Juraj; Majer, Ivan; Novosadova, Helena; Tedla, Miroslav; Paulovicova, Ema; Kantarova, Daniela
- Abstract
Background and objective Pulmonary sarcoidosis ( PS) is characterized by the formation of granulomas in the lungs and has been associated with infection by microorganisms. Triggering receptor expressed on the surface of myeloid cells ( TREM)-1 is overexpressed in response to infection while TREM-2 is involved in granuloma formation. We hypothesized that these receptors are overexpressed in PS and might be useful for diagnostic testing. Methods Cell surface TREM-1 and TREM-2 expression in cells obtained at bronchoalveolar lavage ( BAL) was measured in individuals with sarcoidosis ( n = 26) and compared with that seen in individuals with other interstitial lung diseases ( ILD) ( n = 27). Results TREM-1 and TREM-2 expression was significantly increased in sarcoidosis compared with other ILD: total number of TREM-1, P = 0.0039 (23.81 vs 13.50 cells/μl), TREM-2, P < 0.0001 (32.81 vs 7.76 cells/μl); percentage of TREM-1: P = 0.0002 (41.30% vs 15.70%), TREM-2: P < 0.0001 (34% vs 9.60%); and mean fluorescence of TREM-1: P = 0.0005 (5.43 vs 1.96), TREM-2: P = 0.0011 (6.85 vs 2.77). Increase in both of these receptors seems to be typical for PS. In discriminating sarcoidosis from other ILD, the specificity (96%) and sensitivity (72%) of the combination of TREM-1 and TREM-2 was high. Conclusions Increased TREM-1 and TREM-2 cell surface expression is observed in sarcoidosis. Evaluation of BAL cell expression of both of these receptors may serve as a diagnostic marker for sarcoidosis.
- Subjects
BRONCHOALVEOLAR lavage; INTERSTITIAL lung diseases; SARCOIDOSIS diagnosis; GRANULOMA; EXTRACELLULAR fluid; SEPSIS
- Publication
Respirology, 2013, Vol 18, Issue 3, p455
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12028