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- Title
Myocardial Contractility and Relaxation After Deep Hypothermic Circulatory Arrest in a Neonatal Piglet Model.
- Authors
Tirilomis, Theodor; Popov, Aron-Frederik; Liakopoulos, Oliver J.; Schmitto, Jan D.; Bensch, Marc; Steinke, Katja; Coskun, K. Oguz; Schoendube, Friedrich A.
- Abstract
Cooling before circulatory arrest or ischemic arrest has been reported to influence myocardial performance in isolated neonatal hearts. The aim of the present study was to analyze indices of myocardial contractility and relaxation in an in vivo neonatal model after deep hypothermic circulatory arrest (DHCA). DHCA (18°C; DHCA group; n = 8) or mild hypothermic cardiopulmonary bypass ([MH-CPB] 32°C; MH-CPB group; n = 10) was applied in newborn piglets. After reperfusion (60 and 120 min), left ventricular dP/dtmax increased in DHCA and MH-CPB, while −dP/dtmax decreased slightly in DHCA and increased in MH-CPB. Nevertheless, the differences between the two groups did not reach statistical significance. In conclusion, left ventricular contractility remained stable after reperfusion following DHCA, to some degree at the expense of the diastolic function.
- Subjects
CARDIAC surgery; PIGLETS; CARDIOPULMONARY bypass; CARDIAC contraction; CORONARY disease
- Publication
Artificial Organs, 2012, Vol 36, Issue 1, p101
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1111/j.1525-1594.2011.01242.x