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- Title
Roles of Cysteine Proteases in Biology and Pathogenesis of Parasites.
- Authors
Yang, Nawu; Matthew, Maurice A.; Yao, Chaoqun
- Abstract
Cysteine proteases, also known as thiol proteases, are a class of nucleophilic proteolytic enzymes containing cysteine residues in the enzymatic domain. These proteases generally play a pivotal role in many biological reactions, such as catabolic functions and protein processing, in all living organisms. They specifically take part in many important biological processes, especially in the absorption of nutrients, invasion, virulence, and immune evasion of parasitic organisms from unicellular protozoa to multicellular helminths. They can also be used as parasite diagnostic antigens and targets for gene modification and chemotherapy, as well as vaccine candidates, due to their species and even life-cycle stage specificity. This article highlights current knowledge on parasitic cysteine protease types, biological functions, and their applications in immunodiagnosis and chemotherapy.
- Subjects
CYSTEINE proteinases; PARASITE antigens; BIOLOGY; UNICELLULAR organisms; PARASITES
- Publication
Microorganisms, 2023, Vol 11, Issue 6, p1397
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms11061397