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- Title
Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines.
- Authors
Akimov, M. G.; Dudina, P. V.; Fomina-Ageeva, E. V.; Gretskaya, N. M.; Bosaya, A. A.; Rudakova, E. V.; Makhaeva, G. F.; Kagarlitsky, G. O.; Eremin, S. A.; Tsetlin, V. I.; Bezuglov, V. V.
- Abstract
The antioxidant activity and protective effect in the toxicity model of H2O2 were studied for arachidonic (AA-CHOL), docosahexaenoic (DHA-CHOL), linoleic (Ln-CHOL), and oleic (Ol-CHOL) fatty acids, as well as arachidonoyl dicholine (AA-diCHOL) and O-arachidonoyl bistetramethylaminoisopropanol (ABTAP). AA-CHOL, DHA-CHOL and Ln-CHOL provided a 20% increase in cell survival. AA-CHOL, AA-diCHOL, Ol-CHOL, and ABTAP had a radical-scavenging effect in the ABTS test, approximately equal to the activity of a standard radical scavenger Trolox.
- Subjects
CHOLINE; OLEIC acid; ANTIOXIDANTS; FATTY acids
- Publication
Doklady Biochemistry & Biophysics, 2020, Vol 491, Issue 1, p93
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672920020027