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- Title
Serum 25-hydroxyvitamin D concentration does not independently predict incident diabetes in older women.
- Authors
Schafer, A. L.; Napoli, N.; Lui, L.; Schwartz, A. V.; Black, D. M.
- Abstract
Aims To investigate whether 25-hydroxyvitamin D concentration was associated with incident diabetes in a large cohort of older women. Methods Data were analysed from women included in the Study of Osteoporotic Fractures, a cohort of community-dwelling women aged ≥65 years at enrolment. Serum 25-hydroxyvitamin D concentration was assessed at the year 6 visit, as were BMI and other factors associated with vitamin D and/or diabetes. Diabetes status was determined at each subsequent visit by self-report and medication use. Only those without prevalent diabetes at the year 6 visit were included in the present analysis ( N = 5463, mean age 76.5 years). Results During a mean ± sd follow-up of 8.6 ± 4.4 years, incident diabetes was reported in 320 participants. The mean BMI was higher in those with a 25-hydroxyvitamin D concentration <20 ng/ml (<50 nmol/l) than in those with concentrations 20-30 or ≥30 ng/ml [50-74 or ≥75 nmol/l ( P < 0.0001)]. A higher 25-hydroxyvitamin D concentration was associated with a 13% lower risk of incident diabetes after adjustment for age and clinic site [hazard ratio 0.87, 95% CI 0.76-0.99, per sd increase in 25-hydroxyvitamin D]; however, the addition of BMI to the model attenuated the estimated effect (hazard ratio 0.97, 95% CI 0.86-1.11). Adjustment for additional potential confounders yielded similar results. Conclusions Serum 25-hydroxyvitamin D does not independently predict incident diabetes in older women. Although those with higher 25-hydroxyvitamin D concentrations are less likely to develop diabetes, this is mainly explained by their lower BMI.
- Subjects
DIABETES risk factors; OSTEOPOROSIS diagnosis; GLUCOSE metabolism; AGE distribution; CELL physiology; DIABETES; ALCOHOL drinking; VITAMIN D; DATA analysis; VITAMIN D deficiency; BODY mass index; PROPORTIONAL hazards models; DESCRIPTIVE statistics; DISEASE complications; DIAGNOSIS
- Publication
Diabetic Medicine, 2014, Vol 31, Issue 5, p564
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.12368