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- Title
Biomechanical Profiling of Caenorhabditis elegans Motility.
- Authors
Krajacic, Predrag; Xiaoning Shen; Purohit, Prashant K.; Arratia, Paulo; Lamitina, Todd
- Abstract
Caenorhabditis elegans locomotion is a stereotyped behavior that is ideal for genetic analysis. We integrated video microscopy, image analysis algorithms, and fluid mechanics principles to describe the C elegans swim gait. Quantification of body shapes and external hydrodynamics and model-based estimates of biomechanics reveal that mutants affecting similar biological processes exhibit related patterns of biomechanical differences. Therefore, biomechanical profiling could be useful for predicting the function of previously unstudied motility genes.
- Subjects
CAENORHABDITIS elegans; GENETIC research; VIDEO microscopy; IMAGE analysis; FLUID mechanics; HYDRODYNAMICS; BIOMECHANICS
- Publication
Genetics, 2012, Vol 191, Issue 3, p1015
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.112.141176