We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers.
- Authors
Wood, Susan K.; Sgoifo, Andrea; Scotti, Melissa
- Abstract
Exposure to stress or traumatic events can lead to the development of depression and anxiety disorders. In addition to the debilitating consequences on mental health, patients with psychiatric disorders also suffer from autonomic imbalance, making them susceptible to a variety of medical disorders. Emerging evidence utilizing spectral analysis of heart rate variability (HRV), a reliable non-invasive measure of cardiovascular autonomic regulation, indicates that patients with depression and various anxiety disorders (i.e., panic, social, generalized anxiety disorders, and post traumatic stress disorder) are characterized by decreased HRV. Social stressors in rodents are ethologically relevant experimental stressors that recapitulate many of the dysfunctional behavioral and physiological changes that occur in psychological disorders. In this review, evidence from clinical studies and preclinical stress models identify putative biomarkers capable of precipitating the comorbidity between disorders of the mind and autonomic dysfunction. Specifically, the role of corticotropin releasing factor, neuropeptideY and inflammation are investigated. The impetus for this review is to highlight stress-related biomarkers that may prove critical in the development of autonomic imbalance in stress -related psychiatric disorders.
- Subjects
PSYCHOLOGICAL stress research; BIOMARKERS; MENTAL illness risk factors; DYSAUTONOMIA; CORTICOTROPIN releasing hormone; NEUROPEPTIDE Y; INFLAMMATION
- Publication
Frontiers in Psychology, 2014, Vol 5, p1
- ISSN
1664-1078
- Publication type
Article
- DOI
10.3389/fpsyg.2014.00950