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- Title
Comparative analyses of nuclear proteome: extending its function.
- Authors
Narula, Kanika; Datta, Asis; Chakraborty, Niranjan; Chakraborty, Subhra
- Abstract
Organeller proteomics is an emerging technology that is critical in determining the cellular signal transduction pathways. Nucleus, the regulatory hub of the eukaryotic cell is a dynamic system and a repository of various macromolecules that serve as modulators of such signaling that dictate cell fate decisions. Nuclear proteins (NPs) are predicted to comprise about 10-20% of the total cellular proteins, suggesting the involvement of the nucleus in a number of diverse functions. Indeed, NPs constitute a highly organized but complex network that plays diverse roles during development and physiological processes. In plants, relatively little is known about the nature of the molecular components and mechanisms involved in coordinating NP synthesis, their action and function. Proteomic study hold promise to understand the molecular basis of nuclear function using an unbiased comparative and differential approach. We identified a few hundred proteins that include classical and non-canonical nuclear components presumably associated with variety of cellular functions impinging on the complexity of nuclear proteome. Here, we review the nuclear proteome based on our own findings, available literature, and databases focusing on detailed comparative analysis of NPs and their functions in order to understand how plant nucleus works. The review also shed light on the current status of plant nuclear proteome and discusses the future prospect.
- Subjects
PLANT proteomics; COMPARATIVE studies; PLANT cellular signal transduction; EUKARYOTIC cells; CELL nuclei; MACROMOLECULES; NUCLEAR proteins; PLANT physiology
- Publication
Frontiers in Plant Science, 2013, Vol 4, p1
- ISSN
1664-462X
- Publication type
Article
- DOI
10.3389/fpls.2013.00100