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- Title
Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice.
- Authors
Kaur Grewal, Amarjot; Singh Jaggi, Amteshwar; Chand Rana, Avtar; Singh, Nirmal
- Abstract
The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of grip strength and motor coordination in Swiss albino mice. Administration of carbamazepine (16 mg/kg, i.p.) before global cerebral ischaemia significantly attenuated cerebral infarct size and improved the motor performance. However, administration of indomethacin (100 mg/kg, i.p.) attenuated the neuroprotective effect of carbamazepine. Mexiletine (50 mg/kg, i.p.) did not produce significant neuroprotective effect. It may be concluded that the neuroprotective effect of carbamazepine may be due to increase in synthesis of neurosteroids perhaps by activating enzyme (3α HSD) as indomethacin attenuated the neuroprotective effect of carbamazepine. The sodium channel blocking effect of carbamazepine may not be involved in neuroprotection as mexiletine, a sodium channel blocker, did not produce significant neuroprotective effect.
- Subjects
CAROTID artery; TREATMENT of reperfusion injuries; MEXILETINE; SODIUM channel blockers; CARBAMAZEPINE; ANIMAL disease models; CEREBRAL ischemia treatment; THERAPEUTICS
- Publication
Korean Journal of Physiology & Pharmacology, 2013, Vol 17, Issue 6, p485
- ISSN
1226-4512
- Publication type
Article
- DOI
10.4196/kjpp.2013.17.6.485