We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amacrine-to-amacrine cell inhibition: Spatiotemporal properties of GABA and glycine pathways.
- Authors
CHEN, XIN; HSUEH, HAIN ANN; WERBLIN, FRANK S.
- Abstract
We measured the spatial and temporal properties of GABAergic and glycinergic inhibition to amacrine cells in the whole-mount rabbit retina. The amacrine cells were parsed into two morphological classes: narrow-field cells with processes spreading less than 200 μm and wide-field cells with processes extending more than 300 μm. The inhibition was also parsed into two types: sustained glycine and transient GABA. Narrow-field amacrine cells receive 1) very transient GABAergic inhibition with a fast onset latency of 140 ± 16 ms decaying to 30% of the peak level within 208 ± 27 ms elicited broadly over a lateral distance of up to 1500 μm and 2) sustained glycinergic inhibition with a medium onset latency of 286 ± 23 ms that was elicited over a spatial area often broader than the processes of the narrow-field amacrine cells. Wide-field amacrine cells received sustained glycinergic inhibition but no broad transient GABAergic inhibition. Surprisingly, neither of these amacrine cell classes received sustained local GABAergic inhibition, commonly found in an earlier study of ganglion cells.
- Subjects
GABA; GLYCINE; RETINAL ganglion cells; LABORATORY rabbits; CELL morphology; VETERINARY cytology
- Publication
Visual Neuroscience, 2011, Vol 28, Issue 3, p193
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523811000137