We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synaptic release at mammalian bipolar cell terminals.
- Authors
WAN, QUN-FANG; HEIDELBERGER, RUTH
- Abstract
Bipolar cells play a vital role in the transfer of visual information across the vertebrate retina. The synaptic output of these neurons is regulated by factors that are extrinsic and intrinsic. Relatively little is known about the intrinsic factors that regulate neurotransmitter exocytosis. Much of what we know about intrinsic presynaptic mechanisms that regulate glutamate release has come from the study of the unusually large and accessible synaptic terminal of the goldfish rod-dominant bipolar cell, the Mb1 bipolar cell. However, over the past several years, examination of presynaptic mechanisms governing neurotransmitter release has been extended to the mammalian rod bipolar cell. In this review, we discuss the recent advances in our understanding of synaptic vesicle dynamics and neurotransmitter release in rodent rod bipolar cells and consider how these properties help to shape the synaptic output of the mammalian retina.
- Subjects
NEURAL transmission; SYNAPSES; SENSORY neurons; CELL physiology; EXOCYTOSIS; ENDOCYTOSIS; RETINA; SYNAPTIC vesicles
- Publication
Visual Neuroscience, 2011, Vol 28, Issue 1, p109
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523810000453