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- Title
Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome – a randomized, double-blind, controlled study.
- Authors
SIMRÉN, M.; ÖHMAN, L.; OLSSON, J.; SVENSSON, U.; OHLSON, K.; POSSERUD, I.; STRID, H.
- Abstract
Background The effects of probiotic bacteria in IBS remain controversial. Aim To study the effects of a probiotic product on IBS symptoms. Methods We randomized 74 IBS patients to receive 8 weeks of daily treatment with 400 mL milk fermented with the yoghurt bacteria and containing Lactobacillus paracasei, ssp. paracasei F19, Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 (Cultura; active) or acidified milk without these bacteria (control). The primary endpoint was the proportion of subjects reporting adequate relief of their IBS symptoms at least 50% of the weeks. IBS symptom severity, psychological symptoms and quality of life were assessed. Results The proportion of responders was 38% (14/37 patients) in the active group and 27% (10/37 patients) in the control group ( P = 0.3). IBS symptom severity improved significantly in both groups during the treatment period. This change was greater in the active group during the first 2 weeks, but thereafter, no significant group differences were seen. Conclusions We could not detect a clearly positive effect of fermented milk containing three probiotic bacteria on GI symptoms in IBS patients compared with the control treatment. However, a trend towards a more favourable effect during the first weeks was seen in the active group. Aliment Pharmacol Ther 31, 218–227
- Subjects
CLINICAL trials; FERMENTED milk; PROBIOTICS; INFLAMMATORY bowel diseases; LACTOBACILLUS
- Publication
Alimentary Pharmacology & Therapeutics, 2010, Vol 31, Issue 2, p218
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2009.04183.x