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- Title
Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease.
- Authors
Han, Ian C.; Tadarati, Mongkol; Scott, Adrienne W.
- Abstract
<bold>Importance: </bold>Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography.<bold>Observations: </bold>Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with hemoglobin SS disease and 1 patient with hemoglobin SC disease) were included. The mean age was 37.6 years. Five of 10 eyes (50%) had retinal thinning that was identified using spectral-domain optical coherence tomography. Each of these eyes had corresponding loss of vascular density in the superficial or deep retinal plexus (or both).<bold>Conclusions and Relevance: </bold>Optical coherence tomographic angiography provides a novel way to view the retinal vasculature, including the superficial and deep capillary plexus, and may provide a sensitive method for identifying macular vascular abnormalities in patients with sickle cell disease.
- Publication
JAMA Ophthalmology, 2015, Vol 133, Issue 11, p1337
- ISSN
2168-6165
- Publication type
journal article
- DOI
10.1001/jamaophthalmol.2015.2824