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- Title
Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men.
- Authors
Xu, Yin; Hiyoshi, Ayako; Brand, Judith S; Smith, Kelsi A; Bahmanyar, Shahram; Alfredsson, Lars; Olsson, Tomas; Montgomery, Scott
- Abstract
Background: Evidence for the association between body mass index (BMI) and multiple sclerosis (MS) among men remains mixed. Objective and methods: Swedish military conscription and other registers identified MS after age of 20 years and BMI at ages 16–20 years (N = 744,548). Results: Each unit (kg/m2) BMI increase was associated with greater MS risk (hazard ratio and 95% confidence interval = 1.034, 1.016–1.053), independent of physical fitness (1.021, 1.001–1.042). Categorised, overweight and obesity were associated with statistically significant raised MS risk compared to normal weight, but not after adjustment for physical fitness. Conclusion: MS risk rises with increasing BMI, across the entire BMI range.
- Subjects
BODY mass index; MULTIPLE sclerosis; DIAGNOSIS; DRAFT (Military service); PHYSICAL fitness
- Publication
Multiple Sclerosis Journal, 2021, Vol 27, Issue 1, p147
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458520928061