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- Title
Salivary gland ultrasonography improves the diagnostic performance of the 2012 American College of Rheumatology classification criteria for Sjögren’s syndrome.
- Authors
Cornec, Divi; Jousse-Joulin, Sandrine; Marhadour, Thierry; Pers, Jacques-Olivier; Boisramé-Gastrin, Sylvie; Renaudineau, Yves; Saraux, Alain; Devauchelle-Pensec, Valérie
- Abstract
Objective. The aim of this study was to evaluate whether salivary gland ultrasonography (SGUS) improves the diagnostic performance of the 2012 ACR classification criteria for SS.Methods. We studied a cohort of 101 patients with suspected SS seen at a single centre in Brittany, France. An SGUS echostructure score ≥2 was considered abnormal. The reference standard was a clinical diagnosis of SS made by a group of experts blinded to SGUS findings.Results. SS was diagnosed in 45 patients. Similar proportions of patients with and without SS had an ocular staining score ≥3. Adding RF positivity and ANA titre ≥1:320 as an alternative to anti-SSA/SSB positivity increased the sensitivity of the serological item without modifying specificity compared with using anti-SSA/SSB alone. SGUS was 60.0% sensitive and 87.5% specific for SS. Adding the SGUS score to the ACR criteria increased sensitivity from 64.4% to 84.4% and only slightly decreased specificity, from 91.1% to 89.3%.Conclusion. The diagnostic performance of the ACR classification criteria for SS is notably improved by adding the SGUS score. SGUS should be included in future classification criteria for SS.
- Subjects
FRANCE; SJOGREN'S syndrome diagnosis; ACADEMIC medical centers; BLOOD testing; CONFIDENCE intervals; FISHER exact test; SJOGREN'S syndrome; ULTRASONIC imaging; SEVERITY of illness index; RECEIVER operating characteristic curves; DATA analysis software; MANN Whitney U Test; SYMPTOMS
- Publication
Rheumatology, 2014, Vol 53, Issue 9, p1604
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keu037