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- Title
Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma.
- Authors
Ding, Xiaofeng; Zhang, Chen; Chen, Huajian; Ren, Minghua; Liu, Xiaodong
- Abstract
Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM. We analyzed cathepsins (cathepsin B, cathepsin D, cathepsin L, and cathepsin Z/X), which are highly associated with the radioresistance of GBM by regulating different types of cell death. Cathepsins could be potential targets for GBM treatment.
- Subjects
CATHEPSINS; CATHEPSIN D; CATHEPSIN B; CELL death; GLIOBLASTOMA multiforme; DRUG target
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 24, p4108
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11244108