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- Title
KMT2A Mutations and High Prevalence of dMMR-associated Mutational Signatures as Prognostic Indicators in Metastatic Colorectal Cancer.
- Authors
Zhihang Han; Chuanjun Song; Dongqing Li; Weiyou Zhu; Jiukang Sun; Jialing Yao; Wenyuan Gan; Fufeng Wang; Xiaodong Yang; Lingjun Zhu
- Abstract
This article discusses a study on metastatic colorectal cancer (mCRC) and its prognostic indicators. The study found that patients with mutations in the BRCA2 and KMT2A genes had worse outcomes after chemotherapy-based treatment. It also identified alterations in the homologous recombination pathway and the KMT2A signaling network as factors associated with shorter progression-free survival. Additionally, patients with higher proportions of defective mismatch repair (dMMR)-related mutational signatures had a worse prognosis. The study acknowledges its limitations and calls for further validation in larger patient cohorts.
- Subjects
COLORECTAL cancer; INTESTINAL cancer; PROGNOSTIC models; DNA sequencing; METASTASIS
- Publication
Journal of Cancer, 2024, Vol 15, Issue 10, p3140
- ISSN
1837-9664
- Publication type
Article
- DOI
10.7150/jca.94410