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- Title
The definition of long COVID used in interventional studies.
- Authors
Haslam, Alyson; Olivier, Timothée; Prasad, Vinay
- Abstract
Introduction: There has been little consensus for a specific definition of long COVID, though several organizations have created varying ones. We sought to examine the definition of long COVID used in ongoing clinical trials. Methods: We searched 'long COVID' and related terms on both PubMed and clinicaltrials.gov for randomized studies that either included patients with long COVID or had a persistent or long‐term COVID‐related outcome and abstracted long COVID definition components. Results: Of the 92 studies, a laboratory‐only confirmed diagnosis of COVID‐19 was stipulated in 54.3% (n = 50) studies. We found eight different time durations specified for how long symptoms needed to have occurred, ranging from 4 to 52 weeks, with 12 weeks being the most common (34.8%; n = 32). 35.9% (n = 33) did not specify a time duration. There were 57 different symptoms specified in total, with a median of one symptom identified per study (range 0–32). 8.7% of trials adhered to NICE or WHO definitions. Conclusion: Standardized definitions of long COVID should be applied in studies assessing this condition to unify and harmonize research on this topic.
- Subjects
NICE (France); POST-acute COVID-19 syndrome; CLINICAL trials; DEFINITIONS; COVID-19 testing
- Publication
European Journal of Clinical Investigation, 2023, Vol 53, Issue 8, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.13989