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- Title
CICATRIZAÇÃO DE FERIDAS DIABÉTICAS COM FATOR DE CRESCIMENTO EPIDÉRMICO: REVISÃO INTEGRATIVA.
- Authors
Campos Oliveira, Bianca; Renaud Baptista de Oliveira, Beatriz Guitton; Deutsch, Gabriela; Soares Pessanha, Fernanda; Rodrigues de Castilho, Selma; Barbosa Luz, Flávio
- Abstract
Objective: To analyse the scientific studies of Human recombinant epithelial growth factor for the healing of diabetic wounds. Methods: A thorough review of the literature was performed in the following databases: PubMed, Scopus and LILACS. Results: 21 articles were selected, most studies were experimental (48%). Complete healing of Human recombinant epithelial growth factor-treated lesions has been reported by 17 articles (81%). Increased granulation tissue has been reported in nine publications (43%). Similarly, the reduction of the lesion area was described in two included articles (10%). Two publication describes the decrease in the number of amputations and oxidative stress and 62% of the articles addressed adverse events associated with the use of the product (13/21), of which the occurrence of tremors, local pain, chills, nausea, superficial infection, burning sensation and bruising were considered priority, considered adverse events light. Only one study showed chest pain as a serious adverse event. Conclusion: Although Human recombinant epithelial growth factor is indicated for topical use in the treatment of diabetic wounds and demonstrates good efficacy, more clinical studies should be developed.
- Subjects
WOUND healing; ONLINE information services; DIABETIC foot; EPIDERMAL growth factor; SYSTEMATIC reviews; TREATMENT effectiveness; OXIDATIVE stress; DESCRIPTIVE statistics; GRANULATION tissue; MEDLINE; WOUND care; EVALUATION
- Publication
Enfermagem em Foco, 2022, Vol 13, p1
- ISSN
2177-4285
- Publication type
Article
- DOI
10.21675/2357-707X.2022.v13.e-202221ESP1