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- Title
Pretreatment ethyl glucuronide levels predict response to a contingency management intervention for alcohol use disorders among adults with serious mental illness.
- Authors
McDonell, Michael Gerard; Leickly, Emily; McPherson, Sterling; Skalisky, Jordan; Hirchak, Katherine; Oluwoye, Oladunni; Srebnik, Debra; Roll, John Michael; Ries, Richard Kirkland
- Abstract
<bold>Background and Objectives: </bold>This study investigated if pretreatment ethyl glucuronide (EtG) levels corresponding to light (100 ng/mL), heavy (500 ng/mL), and very heavy (1,000 ng/mL) drinking predicted longest duration of alcohol abstinence (LDA) and proportion of EtG-negative urine tests in outpatients receiving a 12-week EtG-based contingency management (CM) intervention for alcohol dependence.<bold>Methods: </bold>Participants were 40 adults diagnosed with alcohol use disorders and serious mental illness who submitted up to 12 urine samples for EtG analysis during a 4-week observation period and were then randomized to 12-weeks of CM for alcohol abstinence and addiction treatment attendance. Alcohol use outcomes during CM as assessed by EtG and self-report were compared across those who did and did not attain a pre-treatment average EtG level of 500 ng/mL-a level that equates to frequent heavy drinking.<bold>Results: </bold>Only the 500 ng/mL cutoff was associated with significant differences in LDA and proportion of EtG-negative samples during CM. Those with a pre-treatment EtG < 500 ng/mL attained a LDA 2.3 (alcohol) to 2.9 (drugs) weeks longer than pre-treatment heavy drinkers.<bold>Discussion and Conclusions: </bold>The EtG biomarker can be used to determine who will respond to a CM intervention for alcohol use disorders and could inform future trials that are designed to be tailored to individual patients.<bold>Scientific Significance: </bold>Results suggest pre-treatment EtG cutoffs equivalent to heavy and very heavy drinking predict outcomes in CM. (Am J Addict 2017;26:673-675).
- Subjects
ETHYL glucuronide; ALCOHOLISM treatment; PEOPLE with mental illness; TEMPERANCE; BIOMARKERS
- Publication
American Journal on Addictions, 2017, Vol 26, Issue 7, p673
- ISSN
1055-0496
- Publication type
journal article
- DOI
10.1111/ajad.12558