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- Title
Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial.
- Authors
Wang, Liang-Jen; Tsai, Ching-Shu; Chou, Wen-Jiun; Kuo, Ho-Chang; Huang, Ying-Hsien; Lee, Sheng-Yu; Dai, Hong-Ying; Yang, Chia-Yu; Li, Chia-Jung; Yeh, Yao-Tsung
- Abstract
We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD who were already receiving a stable dose of methylphenidate (MPH) treatment were enrolled and were randomly assigned to two groups: one receiving add-on Bf-688 (daily bacterial count of 5 × 109 CFUs) (n = 51) and the other receiving a placebo (n = 51). All participants underwent assessments using Conners' Continuous Performance Test (CPT) and Conners' Continuous Auditory Test of Attention (CATA). Additionally, fecal samples were collected at the beginning of the trial (week 0) and at the endpoint (week 12). Remarkably, the group receiving Bf-688 supplementation, but not the placebo group, exhibited significant improvements in omission errors in CPT as well as Hit reaction time in both CPT and CATA. Gut microbiome analysis revealed a significant increase in the Firmicutes to Bacteroidetes ratio (F/B ratio) only in the Bf-688 group. Furthermore, we identified significant negative correlations between N-Glycan biosynthesis and Hit reaction time in both CPT and CATA. Our results demonstrate that the probiotic Bf-688 supplement can enhance neuropsychological performance in children with ADHD, possibly by altering the composition of the gut microbiota, ultimately leading to reduced N-Glycan biosynthesis.
- Subjects
BIFIDOBACTERIUM; ATTENTION-deficit hyperactivity disorder; PLACEBOS; RESEARCH funding; STATISTICAL sampling; GUT microbiome; BRAIN; TREATMENT effectiveness; RANDOMIZED controlled trials; GASTROINTESTINAL system; PSYCHOLOGY of movement; PROBIOTICS; DIETARY supplements; CHILDREN
- Publication
Nutrients, 2024, Vol 16, Issue 14, p2260
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16142260