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- Title
Micronutrient Deficiencies in Patients with Decompensated Liver Cirrhosis.
- Authors
Llibre-Nieto, Gemma; Lira, Alba; Vergara, Mercedes; Solé, Cristina; Casas, Meritxell; Puig-Diví, Valentí; Solé, Gemma; Humanes, Antonia; Grau, Laia; Barradas, Josep Maria; Miquel, Mireia; Sánchez-Delgado, Jordi; Merli, Manuela
- Abstract
Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our main goal was to assess the prevalence of micronutrient deficiencies in patients with decompensated cirrhosis. This was a prospective single-center study including 125 consecutive patients hospitalized for acute decompensation of cirrhosis (mostly of alcoholic etiology). A blood test including trace elements and vitamins was performed on admission. The main micronutrient deficiencies observed were vitamin D (in 94.5%), vitamin A (93.5%), vitamin B6 (60.8%) and zinc (85.6%). Patients in Child-Pugh class C had lower levels of vitamin A (p < 0.0001), vitamin E (p = 0.01) and zinc (p < 0.001), and higher levels of ferritin (p = 0.002) and vitamin B12 (p < 0.001) than those in Child-Pugh class A and B. Patients with a higher model of end-stage liver disease (MELD) score had lower levels of vitamin A (p < 0.0001), vitamin E (p < 0.001), magnesium (p = 0.01) and zinc (p = 0.001), and higher levels of ferritin (p = 0.002) and vitamin B12 (p < 0.0001). Severe hepatic insufficiency correlated with lower levels of zinc, vitamin E and vitamin A, and higher levels of vitamin B12 and ferritin.
- Subjects
VITAMINS; VITAMIN B12; VITAMIN B6 deficiency; VITAMIN E; FERRITIN; VITAMIN deficiency; DEFICIENCY diseases; CIRRHOSIS of the liver; PATIENTS; RISK assessment; HOSPITAL admission &; discharge; VITAMIN A deficiency; SEVERITY of illness index; LIVER diseases; DISEASE prevalence; HOSPITAL care; DESCRIPTIVE statistics; VITAMIN A; MAGNESIUM; MALNUTRITION; MICRONUTRIENTS; TRACE elements; VITAMIN D deficiency; ZINC; LONGITUDINAL method; DISEASE risk factors; DISEASE complications
- Publication
Nutrients, 2021, Vol 13, Issue 4, p1249
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13041249