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- Title
Mg 2+ Transporters in Digestive Cancers.
- Authors
Auwercx, Julie; Rybarczyk, Pierre; Kischel, Philippe; Dhennin-Duthille, Isabelle; Chatelain, Denis; Sevestre, Henri; Van Seuningen, Isabelle; Ouadid-Ahidouch, Halima; Jonckheere, Nicolas; Gautier, Mathieu
- Abstract
Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters' expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.
- Subjects
MAGNESIUM metabolism; CELL lines; CELLULAR signal transduction; GENE expression; HOMEOSTASIS; SURVIVAL; MITOCHONDRIAL RNA; GENOTYPES
- Publication
Nutrients, 2021, Vol 13, Issue 1, p210
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13010210