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- Title
Physical Activity and Low Glycemic Index Mediterranean Diet: Main and Modification Effects on NAFLD Score. Results from a Randomized Clinical Trial.
- Authors
Franco, Isabella; Bianco, Antonella; Mirizzi, Antonella; Campanella, Angelo; Bonfiglio, Caterina; Sorino, Paolo; Notarnicola, Maria; Tutino, Valeria; Cozzolongo, Raffaele; Giannuzzi, Vito; Aballay, Laura R.; Buongiorno, Claudia; Bruno, Irene; Osella, Alberto R.
- Abstract
Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide, and lifestyle modification is the current standard treatment. The aim of the study was to estimate the effect of two different physical activity (PA) programs, a Low Glycemic Index Mediterranean Diet (LGIMD), and their combined effect on the NAFLD score as measured by FibroScan®. Methods: Moderate or severe NAFLD subjects (n = 144) were randomly assigned to six intervention arms during three months. Interventions arms were a control diet, LGIMD, aerobic activity program (PA1), combined activity program (PA2), and LGIMD plus PA1 or LGIMD plus PA2. The data were compared at baseline, at 45 days, and at 90 days. Analysis of variance was performed under the intention-to-treat principle. Results: There was a statistically significant reduction in the NAFLD score after 45 days of treatment in every working arm except for Arm 1 (control diet). After 90 days, the best results were shown by the intervention arms in which LGIMD was associated with PA: LGIMD plus PA1 (−61.56 95% CI −89.61, −33.50) and LGIMD plus PA2 (−38.15 95% CI −64.53, −11.77). Conclusion: All treatments were effective to reduce NAFLD scores, but LGIMD plus PA1 was the most efficient.
- Subjects
AEROBIC exercises; ANALYSIS of variance; COMBINED modality therapy; COMPARATIVE studies; CONFIDENCE intervals; DIET; NON-alcoholic fatty liver disease; GLYCEMIC index; HEALTH outcome assessment; STATISTICAL sampling; RANDOMIZED controlled trials; PHYSICAL activity; DESCRIPTIVE statistics; MEDITERRANEAN diet
- Publication
Nutrients, 2021, Vol 13, Issue 1, p66
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13010066