We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study.
- Authors
Sotomayor, Camilo G.; Minović, Isidor; Eggersdorfer, Manfred L.; Riphagen, Ineke J.; de Borst, Martin H.; Dekker, Louise H.; Nolte, Ilja M.; Frank, Jan; van Zon, Sander K.R.; Reijneveld, Sijmen A.; van der Molen, Jan C.; Vos, Michel J.; Kootstra-Ros, Jenny E.; Rodrigo, Ramón; Kema, Ido P.; Navis, Gerjan J.; Bakker, Stephan J.L.
- Abstract
Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.
- Subjects
LIPIDS; VITAMIN E; VITAMINS; SOCIOECONOMIC factors
- Publication
Nutrients, 2020, Vol 12, Issue 2, p580
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12020580