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- Title
Curcumin, Hormesis and the Nervous System.
- Authors
Concetta Scuto, Maria; Mancuso, Cesare; Tomasello, Barbara; Laura Ontario, Maria; Cavallaro, Andrea; Frasca, Francesco; Maiolino, Luigi; Trovato Salinaro, Angela; Calabrese, Edward J.; Calabrese, Vittorio
- Abstract
Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin.
- Subjects
CURCUMIN; ANTIOXIDANTS; DOSE-response relationship in biochemistry; MOLECULAR structure; NERVOUS system; NEURODEGENERATION; OXIDOREDUCTASES; THERAPEUTICS
- Publication
Nutrients, 2019, Vol 11, Issue 10, p2417
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11102417