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- Title
Pattern and Visual Prognostic Factors of Behcet's Uveitis in Northwest Iran.
- Authors
Ghavidel, Leila Alizadeh; Bagheri, Masood; Mousavi, Farideh; Rezaei, Leila; Hazeri, Somayyeh; Hashemi, Hesam-Sadat
- Abstract
Purpose: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. Methods: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a period of 17 years between 2004 and 2021. Results: The prevalence of Behcet's uveitis (BU) was more common in females and patients in the fourth decade of life. Ninety-five patients (47.5%) had evidence of ocular involvement in the initial ophthalmologic evaluation, and 171 patients (85.5%) manifested evidence of BU during the follow-up visits of which bilateral non-granulomatous panuveitis was the most common anatomical pattern of involvement (32.9%) followed by posterior (27.6%), anterior (26.5%), and intermediate (13.8%) uveitis. The prevalent accompanying signs were oral aphthous (67%), skin lesions (29%), and genital ulcers (19.5%). Cystoid macular edema (CME) was the most frequent ocular complication (62%), followed by cataract (57.5%) and epiretinal membranes (ERM) (36.5%). Univariate analysis showed the following determinants: male gender, younger age at onset, panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis as poorer visual prognostic factors of the disease. Multivariate analysis demonstrated a higher chance of poor visual prognosis of BD in patients with panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis. Conclusion: This cohort study demonstrated an overview on epidemiological patterns of BU along with the visual prognostic factors in Iranian patients.
- Subjects
IRAN; STATISTICS; MACULAR edema; ANALYSIS of variance; BEHCET'S disease; RESEARCH methodology; MULTIVARIATE analysis; ACQUISITION of data; TREATMENT effectiveness; DISEASE prevalence; MEDICAL records; VISUAL acuity; DESCRIPTIVE statistics; CHI-squared test; IRIDOCYCLITIS; DATA analysis software; PROPORTIONAL hazards models; DISEASE risk factors
- Publication
Journal of Ophthalmic & Vision Research, 2022, Vol 17, Issue 2, p242
- ISSN
2008-2010
- Publication type
Article
- DOI
10.18502/jovr.v17i2.10796