We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evidence-based reproductive toxicity of propylthiouracil-induced hypothyroidism in sexually experienced male rats.
- Authors
KEMKA NGUIMATIO, François Xavier; WANKEU NYA, Modeste; DEEH DEFO, Patrick Brice; NGADJUI, Esther; KAMANYI, Albert; KAMTCHOUING, Pierre; WATCHO, Pierre
- Abstract
Hypothyroidism is associated with changes affecting the endocrine, sexual, or reproductive functions via a variety of mechanisms. To investigate some of the mechanisms involved in the reproductive abnormalities due to the hypothyroidism, the pathology was induced in male rats with propylthiouracil (PTU, 10 mg.kg-1 ; per os). Two experiments were conducted. In experiment 1, the effects of hypothyroidism were evaluated on sexual activity after 28 days of PTU treatment. In experiment 2, rats were treated for 56 days and testicular functions, histological analysis as well as fertility were evaluated. Results showed that 28 and 56 days of PTU treatment induced the hypothyroid status. PTU significantly alters sexual behavior, lowered genital sex organ weights, sperm count, viability and motility, sex hormones, and, increased prolactin, cholesterol and testicular oxidative stress. Alterations in sperm morphology, testis histology and fertility potential were also noticed. These results provide further evidence that hypothyroidism seriously impairs sexual behavior, testis functions and fertility of male rat.
- Subjects
HYPOTHYROIDISM; OXIDATIVE stress; HUMAN sexuality
- Publication
Cameroon Journal of Experimental Biology, 2019, Vol 13, Issue 1, p10
- ISSN
1816-0573
- Publication type
Article
- DOI
10.4314/cajeb.v13i1.2