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- Title
Utility of serial 12-lead electrocardiograms in children with Marfan syndrome.
- Authors
Arunamata, Alisa A.; Nguyen, Charles T.; Ceresnak, Scott R.; Dubin, Anne M.; Olson, Inger L.; Murphy, Daniel J.; Selamet Tierney, Elif S.
- Abstract
<bold>Objectives: </bold>The goal of this study was to assess the utility of serial electrocardiograms in routine follow-up of paediatric Marfan patients.<bold>Methods: </bold>Children ⩽18 years who met the revised Ghent criteria for Marfan syndrome and received a 12-lead electrocardiogram and echocardiogram within a 3-month period were included. Controls were matched by age, body surface area, gender, race, and ethnicity, and consisted of patients assessed in clinic with a normal cardiac evaluation. Demographic, clinical, echocardiographic, and electrocardiographic data were collected.<bold>Results: </bold>A total of 45 Marfan patients (10.8 [2.4-17.1] years) and 37 controls (12.8 [1.3-17.1] years) were included. Left atrial enlargement and left ventricular hypertrophy were more frequently present on 12-lead electrocardiogram of Marfan patients compared with controls (12 (27%) versus 0 (0%), p<0.001; and 8 (18%) versus 0 (0%), p=0.008, respectively); however, only two patients with left atrial enlargement on 12-lead electrocardiogram were confirmed to have left atrial enlargement by echocardiogram, and one patient had mild left ventricular hypertrophy by echocardiogram, not appreciated on 12-lead electrocardiogram. QTc interval was longer in Marfan patients compared with controls (427±16 versus 417±22 ms, p=0.03), with four Marfan patients demonstrating borderline prolonged QTc intervals for gender.<bold>Conclusions: </bold>While Marfan patients exhibited a higher frequency of left atrial enlargement and left ventricular hypertrophy on 12-lead electrocardiograms compared with controls, these findings were not supported by echocardiography. Serial 12-lead electrocardiograms in routine follow-up of asymptomatic paediatric Marfan patients may be more appropriate for a subgroup of Marfan patients only, specifically those with prolonged QTc interval at their baseline visit.
- Subjects
MARFAN syndrome; ELECTROCARDIOGRAPHY; PEDIATRIC cardiology; LEFT ventricular hypertrophy; CARDIOGRAPHY
- Publication
Cardiology in the Young, 2018, Vol 28, Issue 8, p1009
- ISSN
1047-9511
- Publication type
journal article
- DOI
10.1017/S1047951118000707