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- Title
Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats.
- Authors
Vasconcelos, Any Carolina Cardoso Guimarães; Vasconcelos, Daniel Fernando Pereira; Silva, Felipe Rodolfo Pereira; França, Luiz Felipe de Carvalho; Alves, Even Herlany Pereira; Di Lenardo, David; Pessoa, Larissa dos Santos; Nascimento, Hélio Mateus Silva; Carvalho, André dos Santos; Sousa, Francisca Beatriz de Melo; Barbosa, André Luiz dos Reis; Medeiros, Jand‐Venes Rolim; Novaes, Pedro Duarte; Mariano, Flávia Sammartino; Lima, Bruno dos Santos; Araujo, Adriano Antunes de Souza; Júnior, Lucindo José Quintans; Oliveira, Aldeídia Pereira
- Abstract
Background and objective: This study aimed to assess the effectiveness of the treatment with alpha‐terpineol (αTPN) complexed with beta‐cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature‐induced periodontitis. Material and Methods: Forty female rats were distributed among the following groups: control (vehicle solution), periodontitis (ligature + vehicle solution), 5 mg/kg of αTPN‐βCD (ligature), and 25 mg/kg of αTPN‐βCD (ligature). Compounds were administered daily via intraperitoneal injection over a 20‐day period. Periodontitis was induced with the bilateral insertion of ligatures around the first lower molars of each rat. Oral parameters, as well as blood biomarkers, were measured: histopathological assessment of the hepatic tissue was carried out using light and transmission electron microscopy. Results: The treatment with αTPN‐βCD significantly improved several oral parameters and blood biomarkers in comparison with rats with periodontitis. In addition, the treatment with αTPN‐βCD significantly ameliorated the steatosis score and reduced the number of lipid droplets and the amount of foamy cytoplasm in the hepatocytes of rats with periodontitis. Conclusion: The results obtained suggest that the treatment with αTPN‐βCD improves several oral and blood parameters in rats with experimental periodontitis. In addition, hepatic alterations caused by periodontitis were ameliorated in the rats treated with αTPN‐βCD.
- Subjects
CYCLODEXTRINS; PERIODONTITIS; THERAPEUTIC use of essential oils; GLUCANS; INTRAPERITONEAL injections; LIGATURE (Surgery); LIVER cells; TREATMENT duration
- Publication
Journal of Periodontal Research, 2020, Vol 55, Issue 6, p877
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/jre.12780