We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prevalence of fimA genotypes of Porphyromonas gingivalis and periodontal health status in Chinese adults.
- Authors
Zhao, L.; Wu, Y.‐F.; Meng, S.; Yang, H.; OuYang, Y.‐L.; Zhou, X.‐D.
- Abstract
Background and Objective: Porphyromonas gingivalis fimbriae play a key role in colonization of the oral cavity. The fimA gene, which encodes fimbrillin ( FimA), can be classified into six types (I–V and Ib) according to nucleotide sequence. In the present study, we investigated the relationship between the prevalence of P. gingivalis-specific fimA genotypes and periodontal health status in Chinese adults. Material and Methods: One-hundred and fifteen patients with chronic periodontitis and 136 periodontally healthy adults were selected. P. gingivalis detection, determination of fimA genotypes, and the co-existence of Actinobacillus actinomycetemcomitans and Tannerella forsythia with various fimA types, were assessed by the polymerase chain reaction. Odds ratios and 95% confidence intervals were calculated for associating the fimA-specific genes with periodontitis. Results: P. gingivalis was detected in 22.1% of healthy subjects and in 81.7% of the patients. A single fimA genotype was detected in most samples. In healthy adults, the most prevalent fimA genotype was type I (66.7%). However, type II was detected most frequently (43.6%) in the patient group, followed by type IV (30.9%). The frequency of co-existing A. actinomycetemcomitans and T. forsythia was highest in type II fimA-positive sites. Statistical analysis revealed that periodontitis was associated with occurrences of type I (odds ratio 0.97), Ib (odds ratio 13.26), II (odds ratio 36.62), III (odds ratio 4.57), IV (odds ratio 22.86) and V (odds ratio 1.19). Conclusion: P. gingivalis type II followed by type IV were considered as disease-associated strains that account for the pathogenesis of chronic periodontitis in Chinese adults.
- Subjects
PORPHYROMONAS gingivalis; GENETIC polymorphisms; PERIODONTITIS; PILI (Microbiology); MICROBIOLOGY; ACTINOBACILLUS; POLYMERASE chain reaction
- Publication
Journal of Periodontal Research, 2007, Vol 42, Issue 6, p511
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.2007.00975.x