We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of prior treatment on selinexor, bortezomib, dexamethasone outcomes in patients with relapsed/refractory multiple myeloma: Extended follow‐up subgroup analysis of the BOSTON trial.
- Authors
Mateos, Maria‐Victoria; Engelhardt, Monika; Leleu, Xavier; Mesa, Mercedes Gironella; Cavo, Michele; Dimopoulos, Meletios; Bianco, Martina; Merlo, Giovanni Marino; Porte, Charles la; Richardson, Paul G.; Moreau, Philippe
- Abstract
Objectives: To analyze the impact of prior therapies on outcomes with selinexor, bortezomib, and dexamethasone (SVd) versus bortezomib and dexamethasone (Vd) in 402 patients with relapsed/refractory multiple myeloma (RRMM) in the phase 3 BOSTON trial. Methods: Post hoc analysis of progression‐free survival (PFS), overall survival (OS), and safety for lenalidomide‐refractory, proteasome inhibitor (PI)‐naïve, bortezomib‐naïve, and one prior line of therapy (1LOT) patient subgroups. Results: At a median follow‐up of over 28 months, clinically meaningful improvements in PFS were noted across all groups with SVd. The median SVd PFS was longer in all subgroups (lenalidomide‐refractory: 10.2 vs. 7.1 months, PI‐naïve: 29.5 vs. 9.7; bortezomib‐naïve: 29.5 vs. 9.7; 1LOT: 21.0 vs. 10.7; p <.05). The lenalidomide‐refractory subgroup had longer OS with SVd (26.7 vs. 18.6 months; HR 0.53; p =.015). In all subgroups, overall response and ≥very good partial response rates were higher with SVd. The manageable safety profile of SVd was similar to the overall patient population. Conclusions: With over 2 years of follow‐up, these clinically meaningful outcomes further support the use of SVd in patients who are lenalidomide‐refractory, PI‐naïve, bortezomib‐naïve, or who received 1LOT (including a monoclonal antibody) and underscore the observed synergy between selinexor and bortezomib.
- Subjects
BOSTON (Mass.); MULTIPLE myeloma; BORTEZOMIB; CLINICAL trials; PROTEASOME inhibitors; SUBGROUP analysis (Experimental design)
- Publication
European Journal of Haematology, 2024, Vol 113, Issue 2, p242
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.14223