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- Title
Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review.
- Authors
Ponziani, Francesca Romana; Caruso, Cristiano; Baglivo, Ilaria; Macagno, Francesco; Gasbarrini, Antonio; Santopaolo, Francesco; Giustiniani, Maria Cristina; Colantuono, Stefania; Pompili, Maurizio
- Abstract
Inflammatory tissue damage plays a role in the onset, progression, and exacerbation of various chronic autoimmune and metabolic diseases such as autoimmune hepatitis. Here we present a case of autoimmune hepatitis with liver eosinophilic infiltrate in a severe eosinophilic asthma patient who failed conventional immunosuppressive treatment and showed improvement in gastrointestinal symptoms after anti-interleukin-5 receptor treatment. Our case highlights the potential role of eosinophils in initiating or worsening liver inflammation in autoimmune liver disease. The link between eosinophilic inflammation, barrier damage, and chronic autoimmune diseases should be considered in clinical practice.
- Subjects
AUTOIMMUNE hepatitis; LITERATURE reviews; CHRONIC active hepatitis; HEPATITIS; AUTOIMMUNE diseases; ASTHMATICS; LIVER diseases
- Publication
Italian Journal of Medicine, 2023, Vol 17, Issue 3, p6
- ISSN
1877-9344
- Publication type
Article
- DOI
10.4081/itjm.2023.1619