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- Title
Novel broad spectrum virucidal molecules against enveloped viruses.
- Authors
Civra, Andrea; Lembo, David; Cagno, Valeria; Tapparel, Caroline; Tintori, Cristina; Tiberi, Marika; Botta, Lorenzo; Poli, Giulio; Brai, Annalaura; Botta, Maurizio; Cavalli, Roberta
- Abstract
Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses. For this reason, the identification of broad spectrum antiviral compounds provides a valuable opportunity for developing efficient antiviral therapies. Here we report on a class of rhodanine and thiobarbituric derivatives displaying a broad spectrum antiviral activity against seven different enveloped viruses including an HSV-2 acyclovir resistant strain with favorable selectivity indexes. Due to their selective action on enveloped viruses and to their lipid oxidation ability, we hypothesize a mechanism on the viral envelope that affects the fluidity of the lipid bilayer, thus compromising the efficiency of virus-cell fusion and preventing viral entry.
- Subjects
VIRUS diseases; DEATH; ANTIVIRAL agents; DRUG therapy; DENGUE viruses
- Publication
PLoS ONE, 2018, Vol 13, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0208333