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- Title
Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism.
- Authors
ALTUNTAŞ, Ülger; GÖKCE, İbrahim; DENİZ, Neslihan Çiçek; BENZER, Meryem; TUĞTEPE, Halil; GÜVEN, Serçin; YILDIZ, Nurdan; ALPAY, Harika
- Abstract
Secondary pseudohypoaldosteronism (PHA) is a rare condition that presents with hyperkalemia, hyponatremia, and metabolic acidosis, which develops due to renal tubular unresponsiveness to aldosterone. It may be seen in infants with obstructive uropathy and acute pyelonephritis. Three important reasons of the aldosterone unresponsiveness of the tubules are early infancy kidney, obstructive uropathy, and urinary tract infection. Besides other findings, diagnosis is established with highly increased plasma aldosterone and renin levels. In infants who present with hyperkalemia, hyponatremia, and metabolic acidosis, PHA should be considered in the differential diagnosis of congenital adrenal hyperplasia. Urinary ultrasonography and urine analysis should be performed in these patients. Herein, we present two patients with secondary PHA caused by posterior urethral valves.
- Subjects
URETHRA abnormalities; INBORN errors of metabolism; URETHRAL obstruction; DISEASE complications
- Publication
Marmara Medical Journal, 2017, Vol 30, Issue 2, p119
- ISSN
1019-1941
- Publication type
Article
- DOI
10.5472/marumj.344826