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- Title
Acute hyperhydration reduces athlete biological passport OFF-hr score.
- Authors
Bejder, J.; Hoffmann, M. F.; Ashenden, M.; Nordsborg, N. B.; Karstoft, K.; Mørkeberg, J.
- Abstract
Anecdotal evidence suggests that athletes hyperhydrate to mask prohibited substances in urine and potentially counteract suspicious fluctuations in blood parameters in the athlete biological passport ( ABP). It is examined if acute hyperhydration changes parameters included in the ABP. Twenty subjects received recombinant human erythropoietin ( rhEPO) for 3 weeks. After 10 days of rhEPO washout, 10 subjects ingested normal amount of water (∼ 270 mL), whereas the remaining 10 ingested a 1000 mL bolus of water. Blood variables were measured 20, 40, 60, and 80 min after ingestion. Three days later, the subjects were crossed-over with regard to water ingestion and the procedure was repeated. OFF-hr was reduced by ∼ 4%, ∼ 3%, and ∼ 2% at 40, 60, and 80 min, respectively, after drinking 1000 mL of water, compared with normal water ingestion ( P < 0.05). Forty percent of the subjects were identified with atypical blood profiles (99% specificity level) before drinking 1000 mL of water, whereas 11% ( n = 18), 10% and 11% ( n = 18) were identified 40, 60, and 80 min, respectively, after ingestion. This was different ( P < 0.05) compared with normal water intake, where 45% of the subjects were identified before ingestion, and 54% ( n = 19), 45%, and 47% ( n = 19) were identified 40, 60, and 80 min, respectively, after ingestion. In conclusion, acute hyperhydration reduces ABP OFF-hr and reduces ABP sensitivity.
- Subjects
ERYTHROCYTES; BLOOD testing; BLOOD plasma; BLOOD volume; CROSSOVER trials; DIAGNOSTIC errors; DOPING in sports; DRUG use testing; ERYTHROPOIETIN; HEMATOCRIT; HEMOGLOBINS; PROBABILITY theory; RESEARCH funding; RETICULOCYTES; SERUM albumin; STATISTICS; T-test (Statistics); WATER; DATA analysis; MULTIPLE regression analysis; REPEATED measures design; OXYGEN consumption; DATA analysis software
- Publication
Scandinavian Journal of Medicine & Science in Sports, 2016, Vol 26, Issue 3, p338
- ISSN
0905-7188
- Publication type
Article
- DOI
10.1111/sms.12438