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- Title
Clomipramine affects sexual behavior and reproductive functions in male rats.
- Authors
Shekar, Sheshadri; Satyanarayana, S.; Kumar, K. Eswar; Vivek, B.; Velmurugan, C.; Kumar, B. S. Ashok
- Abstract
Aim of the study The present study investigated the influence of Clomipramine (Clmp) on male rat's sexual behavior, histology of testes and serum testosterone concentration. Material and Methods The study was conducted on male Sprague-Dawley rats in four groups of 12 rats each. Group I served as control and the therapeutic dose of 27mg/kg was given to Group II, III and IV as half therapeutic dose (½TD), therapeutic dose (TD) & double the therapeutic dose (2TD) of Clmp respectively. Sexual behavior of male rats was studied on 0, 15th, 30th & 60th days by challenging them with female rats in estrous phase. After 30 days treatment, blood samples were collected from half of the animals in each group and sacrificed, remaining animals on 60th day. Testes were collected and processed for histopathological examination. Serum separated and stored at -200C for testosterone estimation. Results and Conlusions Our study indicated that Clmp produced dose & time dependent sexual dysfunction. It also showed that ½TD of Clmp impaired the sexual behavior without decreasing the testosterone levels, TD & 2TD of Clmp produced sexual dysfunction and also decreased the serum testosterone levels and testicular cells count. Reduction in percentage of rats mounted, intromitted and ejaculated was observed dose and time dependently in all the doses of Clmp tested. All the latencies like mount latency, intromission latency, ejaculation latency and post ejaculatory pause were increased with all the doses of Clmp. Significant fall in testosterone was observed in TD and 2TD at the end of 30 days and 60 days. Reduction in testicular cell count was observed in ½TD, TD, 2TD after 30 days and further decline was observed at the end of 60 days treatment. However this was significant in TD and 2TD treatment groups.
- Subjects
ANIMAL sexual behavior; EFFECT of drugs on reproduction; LABORATORY rats; ESTRUS; PHARMACEUTICAL research; PHYSIOLOGY
- Publication
International Journal of Health Science, 2010, Vol 3, Issue 3, p341
- ISSN
1791-4299
- Publication type
Article