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- Title
Risk of Hepatocellular Carcinoma After Spontaneous Clearance of Hepatitis C Virus and in Noncirrhosis Chronic Hepatitis C Patients With Sustained Virological Response: A Systematic Review.
- Authors
Hsu, Christine C; Gopalakrishna, Harish; Mironova, Maria; Lee, Mei-Hsuan; Chen, Chien-Jen; Yang, Hwai-I; Wiese, Manfred; Chang, Kyong-Mi; Wright, Elizabeth C; Abijo, Tomilowo; Feld, Jordan J; Kaplan, David E
- Abstract
In a hepatitis C virus (HCV)–controlled human infection model (CHIM), healthy volunteers are inoculated with HCV and then treated. Residual hepatocellular carcinoma (HCC) risk after viral clearance is an important consideration when evaluating the CHIM. We estimate HCC risk in spontaneously cleared HCV and in noncirrhosis after sustained virological response (SVR) to HCV treatment in a systematic review and using data from 3 cohorts: German anti-D, Taiwan, and US Veterans Affairs (VA). For noncirrhosis SVR, the overall HCC rate is 0.33 per 100 patient-years in meta-analysis. HCC rates for the German, Taiwan, and US Veterans Affairs cohorts are 0, 0.14, and 0.02 per 100 patient-years, respectively. Past hepatitis B virus exposure was not accounted for in the Taiwan cohort, while VA patients were likely tested based on liver disease/risk factors, which may confound HCC outcomes. The German cohort with no HCC after 44 years is most comparable to the CHIM participants. Although it is difficult to precisely estimate HCC risk from an HCV CHIM, the data suggest the risk to be very low or negligible.
- Subjects
ONLINE information services; MEDICAL databases; CHRONIC hepatitis C; MEDICAL information storage &; retrieval systems; META-analysis; CONFIDENCE intervals; SYSTEMATIC reviews; HEPATITIS C; ANTIVIRAL agents; TREATMENT effectiveness; COMPARATIVE studies; DESCRIPTIVE statistics; MEDLINE; DATA analysis software; DISEASE remission; HEPATOCELLULAR carcinoma; DISEASE risk factors; DISEASE complications
- Publication
Clinical Infectious Diseases, 2023, Vol 77, pS245
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad380