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- Title
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection.
- Authors
Maponga, Tongai G; Jeffries, Montenique; Tegally, Houriiyah; Sutherland, Andrew; Wilkinson, Eduan; Lessells, Richard J; Msomi, Nokukhanya; Zyl, Gert van; Oliveira, Tulio de; Preiser, Wolfgang
- Abstract
A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
- Subjects
HIV infections; COVID-19; GENETIC mutation; IMMUNOCOMPROMISED patients; CHRONIC diseases; WOMEN; HIGHLY active antiretroviral therapy; INFECTION; RESEARCH funding; AIDS patients
- Publication
Clinical Infectious Diseases, 2023, Vol 76, Issue 3, pe522
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac548