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- Title
Duration of Protection After Vaccination Against Yellow Fever: A Systematic Review and Meta-Analysis.
- Authors
Kling, Kerstin; Domingo, Cristina; Bogdan, Christian; Duffy, Steven; Harder, Thomas; Howick, Jeremy; Kleijnen, Jos; McDermott, Kevin; Wichmann, Ole; Wilder-Smith, Annelies; Wolff, Robert
- Abstract
The duration of protection after a single dose of yellow fever vaccine is a matter of debate. To summarize the current knowledge, we performed a systematic literature review and meta-analysis. Studies on the duration of protection after 1 and ≥2 vaccine doses were reviewed. Data were stratified by time since vaccination. In our meta-analysis, we used random-effects models. We identified 36 studies from 20 countries, comprising more than 17 000 participants aged 6 months to 85 years. Among healthy adults and children, pooled seroprotection rates after single vaccination dose were close to 100% by 3 months and remained high in adults for 5 to 10 years. In children vaccinated before age 2 years, the seroprotection rate was 52% within 5 years after primary vaccination. For immunodeficient persons, data indicate relevant waning. The extent of waning of seroprotection after yellow fever vaccination depends on age and immune status at primary vaccination.
- Subjects
META-analysis; IMMUNIZATION; SYSTEMATIC reviews; YELLOW fever; VACCINE effectiveness; YELLOW fever vaccines
- Publication
Clinical Infectious Diseases, 2022, Vol 75, Issue 12, p2266
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac580